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 Home / About Us > Dr David St-Pierre

Contact info

Dr David St-Pierre
Université du Québec à Montréal
141, avenue du Président-Kennedy
C.P. 8888, succursale Centre-Ville
Montreal, QC  H3C 3P8

Tel: 1-514-987-3000 ext. 5150
Fax: 1-514-987-6616
E-mail: david.stpierre.uqam@gmail.com

 

Research keywords

  • Gastrointestinal peptides
  • Lipid infiltration
  • Non-alcoholic fatty liver disease
  • Liver
  • Skeletal muscle
  • Metabolism
  • Nutrition
  • Insulin resistance
  • Type 2 diabetes

 

David H St-Pierre, PhD
Professor of Kinanthropology


Biographical Sketch

CIHR Post-Doctoral Fellow, Peptide Physiology and Endocrinology, U. Torino (Molinette Hospital), Torino, Italy (E. Ghigo, F. Broglio; 2007-2010) and CRIUCPQ, U. Laval, Quebec City (D. Richard, K. Cianflone; 2010-2011)

PhD Nutrition (CIHR Studentship), U. Montréal (R. Rabasa-Lhoret; 2003-2006)

MSc Biomedicine, U. Montréal (2000-2002)

BSc Microbiology, McGill (1997-2000)


Click here for pdf CV



Selected Scientific Contributions

1) St-Pierre DH, Wang L and Taché Y. Ghrelin: a novel player in gut-brain regulation of growth hormone and energy balance. NIPS 18:242-246, 2003.
I was among first to synthesize and to study ghrelin and related peptides in vivo. As a consequence, I was invited by Dr Yvette Taché (CURE, UCLA) to co-publish an early invited review in NIPS to sum up known actions of the newly discovered peptide and hypothesize its putative physiological functions. Until now, a number of those have been confirmed, including the influence of ghrelin on food intake, adipogenesis and regulation of GH secretion.

2) St-Pierre DH et al. Hormonal profile associated with the insulin sensitive overweight and obese subjects. Journal of Clinical Endocrinology and Metabolism 92:264-269, 2007.
I was part of a clinical team that carried out studies in insulin-sensitive (ISO) and insulin-resistant (IRO) obese postmenopausal women, using euglycemic/ hyperinsulinemic (EHC) clamps. Unacylated and acylated ghrelin (UAG, AG) profiles were analyzed during the EHC. I was able to establish that ISO women displayed a lower AG/UAG ratio in the fasting condition and during the EHC. A significant decrease in AG in response to the EHC was also observed in ISO but not in IRO women. This article provided the first evidence of specific AG fluctuations in response to an hyperinsulinemic state in humans and reinforced the hypothesis that AG could have a detrimental effect on insulin sensitivity.

3) Miegueu P, St-Pierre DH, Broglio F and Cianflone K. Effect of obestatin, des-acyl ghrelin (dAG), acylated ghrelin and GHRP-6 in 3T3-L1 cell metabolism. J Cell Biochem 112:704-14, 2011.
Before leaving for PDF training in Italy in 2007, I was offered a short training in K. Cianflone’s (Canada Research Chair on Adipose Tissue) lab to study the effects of GI peptides on adipocyte functions. I designed and carried out a set of experiments using 3T3-L1 cells and, after I left for postdoctoral training in Turin, the project was carried on by a PhD student (P. Miegueu) under my co-supervision. It was completed during the year I spent as a PDF in Quebec City in 2010-2011. We also found that motilin, a peptide structurally related to ghrelin, influences pre-, differentiating and mature adipocyte functions. Because this article sheds the light on a so far unsuspected link between motilin, adipocyte functions and obesity, it was the object of a flattering editorial comment (Ceddia R, Am J Physiol, 2011). This work was part of our series of articles describing some of the effects of gastrointestinal peptides on the regulation of adipocyte functions.

Click here for PubMed listing


Research Interests

Areas of Research Interest

My primary research interests are in the integrative aspects of GI peptide physiology in organs and tissues and how GI peptide-based interventions could optimally improve the health of individuals affected by obesity and related insulin resistance, type 2 diabetes (T2D) and ensuing metabolic dysfunctions. My laboratory focuses on better understanding basic mechanistic physiology using state-of-the-art techniques and methods before designing novel interventions to try to modify disease state.

Ongoing Research Projects

The physiological role of gastrointestinal (GI) peptides in man is still largely unknown. I have had a long-lasting interest in studying the role of GI peptides in the regulation of energy balance, especially ghrelin since its discovery in 1999. Current projects going on in my laboratory aim two important features of GI peptides, including the acylated (AG) and unacylated (UAG) forms of ghrelin, as well as motilin, secretin and others, in health and disease:

1) GI peptides and energy balance. We study the influence of GI peptides on appetite and energy expenditure in rodent models, using acute or chronic synthetic peptide administrations performed centrally or peripherally in the animals. We also evaluate the combined effects of GI peptides and specific nutrients on caloric intake. These studies provide critical information regarding food/water intake, energy expenditure and physical activity over a prolonged period of time.

2) GI peptides and excessive lipid infiltration in organs and tissues. Lipid infiltration in organs and tissues is suspected to be a key step in the development of metabolic dysfunctions but related mechanisms remain to be elucidated. We study the influence and functional outcomes of GI peptides in the etiology of excessive lipid infiltration in the liver and skeletal muscles using cell (primary and cell lines) and rodent models. Lipid infiltration is evaluated by fluorescence microscopy and the identity of lipid species is determined by mass spectrometry.

Opportunities for Graduate Student Training

My research facilities offer a unique training environment in peptide physiology, allowing students to explore a wide breadth of basic as well as clinical research subjects of interest. I also interact with a number of prominent research laboratories and clinical facilities located in Canada and abroad. These associations facilitate training opportunities for graduate students and increase access to additional competences, staff, measurement techniques, biological material and major equipment. I am currently considering applications from highly motivated and outstanding PhD and postdoctoral trainees.

   
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