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Dr. Vincent Poitout - Bibliography (Last Five Years)
| Original, Peer-Reviewed Publications |
- S. Jacqueminet, I. Briaud, C. Rouault, G. Reach, V.
Poitout. Inhibition of insulin gene expression
by long-term exposure of pancreatic beta-cells to palmitate
is dependent upon the presence of a stimulatory glucose
concentration. Metabolism 2000, 49: 532-536.
- I. Briaud, C. Rouault, D. Bailbé, B. Portha, G.
Reach, V. Poitout. Glucose-induced insulin
mRNA accumulation is impaired in islets from neonatal streptozotocin-treated
rats. Horm Metab Res 2000, 32: 53-56.
- I. Briaud, J.S. Harmon, C.L. Kelpe, V.B. Segu, V.
Poitout. Lipotoxicity of the pancreatic ß-cell
is associated with glucose-dependent esterification of fatty
acids into neutral lipids. Diabetes 2001, 50: 315-321.
- J.S. Harmon, C.E. Gleason, Y. Tanaka, V. Poitout,
R.P. Robertson. Antecedent hyperglycemia, not hyperlipidemia,
is associated with increased islet triacylglycerol content
and decreased insulin gene expression in Zucker Diabetic
Fatty rats. Diabetes 2001, 50: 2481-2486.
- M. Guerre-Millo, C. Rouault, P. Poulain, J. André,
V. Poitout, J.M. Peters, F.J. Gonzales,
J.C. Fruchart, G. Reach, B. Staels. PPARa null mice are
protected from high-fat diet-induced insulin resistance.
Diabetes 2001, 50: 2809-2814.
- I. Briaud, C.L. Kelpe, L.M. Johnson, P.O.T. Tran, V.
Poitout. Differential effects of hyperlipidemia
on insulin secretion in islets of Langerhans from hyperglycemic
vs. normoglycemic rats. Diabetes 2002, 51: 662-668.
- C.L. Kelpe, L.M. Johnson, V. Poitout.
Increasing triglyceride synthesis inhibits glucose-induced
insulin secretion in isolated rat islets of Langerhans.
A Study Using Adenoviral Expression of Diacylglycerol Acyltransferase.
Endocrinology 2002, 143: 3326-3332.
- S. Matsumoto, S. Qualley , S. Goel , D. Hagman, Ian R.
Sweet, V. Poitout, D. M. Strong , R. P.
Robertson, J. Reems. Effect of the two-layer [University
of Wisconsin solution-Perfluorochemical + O2] method of
pancreas preservation on human islet isolation, as assessed
by the Edmonton isolation protocol. Transplantation 2002,
74: 1414-1419.
- P.C. Guest, S.M. Abdel-Halim, D.J. Gross, A. Clark, V.
Poitout, R. Amaria, C.G. Ostenson, J.C. Hutton.
Proinsulin processing in the Goto-Kakizaki (GK) rat. J Endocrinol
2002, 175: 637-647.
- K. Yaekura, R. Julyan, L. Hays, M. Donelan, D. Baskin,
V. Poitout, C.J. Rhodes. Insulin secretory
deficiency and glucose intolerance in Rab3A null mice. J
Biol Chem 2003, 278: 9715-9721.
- C.L. Kelpe, P.C. Moore, S.D. Parazzoli, B. Wicksteed,
C.J. Rhodes, V. Poitout. Palmitate
inhibition of insulin gene expression is mediated at the
transcriptional level via ceramide synthesis. J Biol
Chem 2003, 278: 30015-30021.
- S. Parker, P.C. Moore, L.M. Johnson, V. Poitout.
Palmitate potentiation of glucose-induced insulin release:
a study using 2-bromopalmitate. Metabolism 2003, 52:1367-1371.
- R. Roduit, C. Nolan, C. Alarcon, P. Moore, A. Barbeau,
V. Delghingaro-Augusto, E. Przybykowski, J. Morin, F. Massé,
B. Massie, N. Ruderman, C. Rhodes, V. Poitout,
M. Prentki. A Role for the malonyl-CoA / long-chain acyl-CoA
pathway of lipid signaling in the regulation of insulin
secretion in response to both fuel and non-fuel stimuli.
Diabetes 2004, 53: 1007-1019.
- P.C. Moore, M.A. Ugas, D.K. Hagman, S.D. Parazzoli, V.
Poitout. Evidence against
the involvement of oxidative stress in fatty-acid inhibition
of insulin secretion. Diabetes 2004, 53: 2610-2616.
- M. F. Pino, D. Z. Ye, K. D. Linning, C.D. Green, B. Wicksteed,
V. Poitout, L. K. Olson. Elevated
glucose attenuates human insulin gene promoter activity
in INS-1 pancreatic ß cells via reduced nuclear factor
binding to the A5/core and Z element. Mol Endocrinol
2005, 19: 1343-1360.
- L. Zhao, M. Guo, T. Matsuoka, D.K. Hagman, S.D. Parazzoli,
V. Poitout, R. Stein. The
islet beta-cell-enriched MafA activator is a central regulator
of insulin gene transcription. J Biol Chem 2005, 280:
11887-11894.
- H. Bihan, C. Rouault, V. Poitout, G.
Reach, B. Staels, M. Guerre-Millo. PPARa contributes to
the adaptive response of pancreatic islets to hyperglycemia.
FEBS Letters 2005, 579: 2284-2288.
- D.K. Hagman, S.D. Parazzoli, V. Poitout.
Palmitate inhibits insulin gene
expression by altering PDX-1 nuclear localization and reducing
MafA expression in isolated rat islets of Langerhans.
J Biol Chem 2005, 280: 32413-32418.
- E. Oseid, P.C. Moore, J. Luo, D.C. Lin, V. Poitout.
Essential role for GPR40 in glucose homeostasis and fatty-acid
potentiation of insulin secretion. Submitted for publication.
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| Communications |
- I. Briaud, C.L. Kelpe, J.S. Harmon, S.A. Metz, V.
Poitout. Palmitate-induced impairment of insulin
gene expression in pancreatic beta-cells is associated with
intracellular accumulation of triacylglycerols. J Investig
Med 2000, 48: A113.
- P.O.T. Tran, C.E. Gleason, V. Poitout,
R.P. Robertson. Sodium salicylate blocks interleukin-1ß-induced
cyclooxygenase gene expression and inhibition of insulin
secretion. J Investig Med 2000, 48: A113.
- P.O.T. Tran, C. E. Gleason, V. Poitout,
R. P. Robertson. Inhibition of cyclooxygenase 2 (COX 2)
and type 3 prostaglandin E receptor (EP3) gene expression
are mechanisms whereby sodium salicylate (SS) interferes
with IL 1 ? inhibition of insulin secretion. Diabetes 2000,
49/Suppl 1: A261.
- I. Briaud, C. L. Kelpe, P.O.T. Tran, V. Poitout.
High-fat diet impairs beta-cell function in Goto-Kakizaki
rats independently of lipotoxicity. Diabetes 2000, 49/Suppl
1: A262.
- J. S. Harmon, I. Briaud, R. P. Robertson, V.
Poitout. An improved method for measurement of
triacylglycerol content in pancreatic islets. Diabetes 2000,
49/Suppl 1: A263
- I. Briaud, C. L. Kelpe, J. S. Harmon, S. A. Metz, V.
Poitout. Palmitate inhibition of glucose-induced
insulin gene expression is associated with increased intracellular
accumulation of neutral lipids in pancreatic beta-cells.
Diabetes 2000, 49/Suppl 1: A415.
- J.S. Harmon, C.E. Gleason, Y. Tanaka, V. Poitout,
R.P. Robertson. Antecedent hyperglycemia, not hyperlipidemia,
is associated with increased islet triacylglycerol content
and decreased insulin gene expression in Zucker Diabetic
Fatty rats. Diabetes 2001, 50/Suppl 2: A319.
- I. Briaud, C.L. Kelpe, L.M. Johnson, P.O.T. Tran, V.
Poitout. Differential effects of hyperlipidemia
on insulin secretion in islets of Langerhans from hyperglycemic
vs. normoglycemic rats. Western Islet Club, San Francisco,
CA, September 2001.
- I. Briaud, C.L. Kelpe, L.M. Johnson, P.O.T. Tran, V.
Poitout. Differential effects of hyperlipidemia
on insulin secretion in islets of Langerhans from hyperglycemic
vs. normoglycemic rats. Beta-cell biology for the 21st century.
National Institutes of Health, Bethesda, MD, November 2001.
- R. Roduit, C. Alarcon, F. Massé, C.L. Kelpe, V.
Poitout, C.J. Rhodes, M. Prentki,. Overexpressing
malonyl-CoA decarboxylase in the cytosol alters lipid partitioning
and glucose-induced insulin secretion in pancreatic beta-cells.
Beta-cell biology for the 21st century. National Institutes
of Health, Bethesda, MD, November 2001.
- V. Poitout, C.L. Kelpe, L. Johnson.
Overexpression of Diacylglycerol-Acyltransferase inhibits
glucose-induced insulin secretion in isolated rat islets
of Langerhans. Diabetes 2002, 51/Suppl 2: A1.
- K. Yaekura, R. Julyan, B.L. Wicksteed, L.B. Hays, C.
Alarcon, D. Baskin, V. Poitout, L.H. Philipson,
C.J. Rhodes. Rab3A Null Mice Develop a Pancreatic ?-cell
Defect Glucose Intolerance due to an Insulin Exocytotic
Defect. Diabetes 2002, 51/Suppl 2: A72.
- S. Matsumoto, S. Qualley , S. Goel , D. Hagman, Ian R.
Sweet, V. Poitout, D. M. Strong, R. P.
Robertson, J. Reems. The effect of the two-layer [University
of Wisconsin solution (UW) / Perfluorochemical+ O2] method
on human islet isolation as assessed by the Edmonton isolation
protocol. American Transplant Meeting 2002.
- H. Bihan, C. Rouault, M. Guerre-Millo, V. Poitout,
B. Staels, G. Reach. Rôle de PPAR? dans l’insulino-sécrétion:
Etude fonctionnelle des îlots de Langerhans de souris
invalidées pour PPAR?. ALFEDIAM 2003.
- C.L. Kelpe, C.S. Sutton, P.C. Moore, B. Wicksteed, C.J.
Rhodes, V. Poitout. Fatty acids inhibit
insulin gene transcription in isolated rat islets of Langerhans.
Keystone symposium “Towards understanding islet biology”
2003.
- C.L. Kelpe, P.C. Moore, C.S. Sutton, Susan D. Parazzoli,
B. Wicksteed, C.J. Rhodes, V. Poitout.
Palmitate inhibition of insulin gene expression in isolated
rat islets is transcriptional and mediated by de novo ceramide
synthesis. Diabetes 2003, 52/Suppl 1: A377.
- M. Prentki, C. Nolan, C. Alarcon, C. Kelpe, E. Przybykowski,
J. Morin, F. Masse, N. Ruderman, C. Rhodes, V. Poitout,
R. Roduit. A role for malonyl-CoA and lipid signaling in
the regulation of insulin secretion in response to both
fuel and non-fuel stimuli. Diabetes 2003, 52/Suppl 1: A383.
- V. Poitout, P.C. Moore, C.S. Sutton,
S.D. Parazzoli, B. Wicksteed, C.J. Rhodes, C.L. Kelpe. Mechanisms
of fatty acid inhibition of insulin gene expression in isolated
rat islets. Diabetologia 2003, 46/Suppl 2: A 177.
- D.K. Hagman, M.A. Ugas, P.C. Moore, S.D. Parazzoli, V.
Poitout. Fatty-acid inhibition of insulin secretion:
In search of a mechanism. Western Region Islet Study Group
Meeting, Seattle, WA, September 2003.
- M.A. Ugas, P.C. Moore, V. Poitout. Fatty-acid
inhibition of insulin secretion: In search of a mechanism.
National Conferences on Undegraduate Research, Indianapolis,
IN, April 2004.
- D.K. Hagman, S.D. Parazzoli, V. Poitout.
Prolonged exposure to palmitate reduces PDX-1 and MafA binding
to the insulin gene promoter. Western Region Islet Study
Group Meeting, Catalina Island, CA, October 2004.
- D.K.Hagman, S.D. Parazzoli, V. Poitout.
Prolonged exposure of isolated rat islets to palmitate reduces
PDX-1 and MafA binding to the insulin gene promoter. Keystone
Symposium: Diabetes Mellitus: Molecular Mechanisms, Genetics
and New Therapies, Keystone, CO, January 2005.
- D.K. Hagman, S.D. Parazzoli, V. Poitout.
Prolonged Exposure of Isolated Rat Islets to Palmitate Reduces
PDX-1 and MafA Binding to the Insulin Gene Promoter. Diabetes
2005, 54/Suppl 1: A399.
- P.C. Moore, D.C. Lin, J. Luo, V. Poitout.
Deletion of the GPR40 gene impairs fatty-acid potentiation
of insulin secretion in isolated mouse islets. Diabetes
2005, 54/Suppl 1: A83.
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