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Original articles
* Asterisk indicates trainee/employee under my
supervision. Seminal papers highlighted
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- Marquette CA, Lawrence I, Polychronakos C and
MF Lawrence. Impedance based DNA chip for direct Tm
measurement. Talanta 2002, 56(4):763-768.
- *Alami Chentoufi A and C Polychronakos.
Insulin expression levels in the thymus modulate insulin-specific
autoreactive T-cell tolerance: The mechanism by which the IDDM2
locus may predispose to diabetes. Diabetes 2002, 51:1383-1390.
- *Zavalkoff SR and C Polychronakos. Evaluation
of conventional blood glucose monitoring as an indicator of integrated
glucose values using a continuous subcutaneous sensor. Diabetes
Care, 2002, 25:1603-1606.
- *Anjos S, Nguyen A, *Ounissi-Benkhala H, *Tessier
MC and C Polychronakos. A common autoimmunity
predisposing a signal peptide variant of the cytotoxic T-lymphocyte
antigen-4 results in inefficient glycosylation of the susceptibility
allele. Journal of Biological Chemistry, 2002, 277(48):46478-46486.
- Polychronakos C and A *Kukuvitis. Parental
genomic imprinting in endocrinopathies. European Journal of
Endocrinology 2002, 147(5):561-569.
- Ducharme FM, Chabot G, Polychronakos C, Glorieux
F and B Mazer. Safety profile of frequent short courses of oral
glucocorticoids in acute pediatric asthma: impact on bone metabolism,
bone density, and adrenal function. Pediatrics 2003,
Feb;11(2):376-83.
- *Punthakee Z, Legault L and C Polychronakos.
Prednisolone in the treatment of adrenal insufficiency: A reevaluation
of relative potency. J Pediatr. 2003, Sep;143(3):402-5.
- Macanovic A, Marquette C, Polychronakos C and
MF Lawrence. Impedance-based detection of DNA sequences using
a silicon transducer with PNA as the probe layer. Nucleic
Acids Research 2004, Jan 22;32(2):E20.
- *Chentoufi A, *Palumbo M and C Polychronakos.
Proinsulin expression by Hassall's corpuscles in the mouse thymus.
Diabetes 2004, 53(2):354-9.
- *Kukuvitis A, Georgiou I, Syrrou M, Andronikou S, Dickerman
A, *Islam A, *McCann J and C Polychronakos. Lack
of association of birth size with polymorphisms of two imprinted
genes, IGF2R and GRB10. J Ped Endocrinol Metab 2004,
17:1215-1220.
- *McCann JA, *Xu YQ, *Frechette R, Guazzarotti R and Polychronakos
C. The insulin-like growth factor-II receptor gene is
associated with type 1 diabetes: evidence of a maternal effect.
J Clin Endocrinol Metab. 2004, 89(11):5700-6.
- *Anjos S, *Tessier MC and C Polychronakos.
Association of the CTLA4 gene with type 1 diabetes: independent
effects of two SNPs on the same haplotype block. J Clin Endocrinol
Metab 2004, 89:5700-6.
- *Mitchell J, *Punthakee Z, Lo B, Bernard B, Chong K, Newman
C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P and C
Polychronakos. Neonatal diabetes, with hypoplastic pancreas,
intestinal atresia and gallbladder hypoplasia: A search for the
etiology of a new autosomal recessive syndrome. Diabetologia
2004, Dec;47(12):2160-7
- *Qu H, *Tessier M-C, Hudson TJ and Polychronakos C.
Confirmation of the association of the R620W polymorphism in the
protein tyrosine phosphatase PTPN22 with type 1 Diabetes in a
family-based study. Journal of Medical Genetics. 2005,
42(3) 266-270.
- *Qu H, Bharaj B, Liu XQ, Curtis JA, Newhook LA, Paterson AD,
Hudson TJ and C Polychronakos. Assessing the
validity of the association between the SUMO4 M55V variant and
risk of type 1 diabetes. Nature Genetics. 2005, 37:111-112.
- *Anjos S, *Shao W, *Marchand L and C Polychronakos.
Allelic effects on gene regulation at the autoimmunity-predisposing
CTLA4 locus: a re-evaluation of the 3' +6230G>A polymorphism.
Genes and Immunity 2005, 6(4):305-11.
- Tessier MC, Qu HQ, Frechette R, Bacot F, Grabs R, Taback SP,
Lawson ML, Kirsch SE, Hudson TJ and Polychronakos C.
Type 1 diabetes and the OAS gene cluster: association with splicing
polymorphism or haplotype? J Med Genet. 43:129-32 2006
- Durinovic-Belló I, *Jelinek E, Schlosser M, Eiermann
T, Boehm BO, Karges W, *Marchand L and Polychronakos C.
Class III alleles at the insulin VNTR polymorphism are associated
with regulatory T-lymphocyte responses to proinsulin epitopes
in HLA-DR4, DQ8 individuals. Diabetes 2005 54:S18-S24.
- Qu H, Tessier M C Tessier, Frechette R, Bacot F, Polychronakos
C. Lack of association of type 1 diabetes with the IL4R
gene. Diabetologia 49:958-961, 2006.
- Legault L, Polychronakos C. Annual incidence
of type 1 diabetes in Quebec between 1989-2000 in children. Clin
Invest Med. 29:10-3, 2006
- *Qu H, *Guo F, Majewski J and Polychronakos C.
Strand bias of complementary single-nucleotide polymorphisms in
transcribed human sequences: evidence for functional effects of
synonymous substitutions. BMC Genomics. 2006 Aug 17;7:213.
- Durinovic-Belló, Rosinger S, Olson JA, Congia M, Ahmad
RC, Rickert M, Hamp J, Kalbacher H, Drijfhout JW, Mellins ED,
Al Dahouk S, Roep BO, Nepom GT, Kamradt T, Maeurer MJ, KargesW,
Boehm BO, Nhan C*, Polychronakos C, McDevitt
HO and Sønderstrup G. DRB1*0401-restricted human T-cell
clone, specific for the major proinsulin 73-90 epitope expresses
a regulatory T helper 2 phenotype. Proc Natl Acad Sci USA.
2006 103(31):11683-8,.
- *Palumbo M, *Levi D, *Chentoufi AA and C Polychronakos.
Insulin-producing thymus epithelial cell lines: generation, characterization,
and evaluation of expression of beta-cell antigens and transcription
factors. Diabetes 2006, 55(9):2595-601
- Marchand L, Polychronakos C. Evaluation of
Polymorphic Splicing in the Mechanism of the Association of the
Insulin Gene with Type 1 Diabetes. Diabetes 2007 Mar;56(3):709-13.
- Qu H., Yang L., Montpetit A., Polychronakos C.
Genetic control of alternative splicing in the TAP2 gene: Possible
implication in the genetics of type 1 diabetes. Diabetes
2007 56:270-275,2007.
- Qu HQ, Marchand L, Frechette R, Bacot F, Lu Y, Polychronakos
C. No association of type 1 diabetes with a functional
polymorphism of the LRAP gene. Molecular Immunology.
44:2145-8, 2007.
- Qu HQ and Polychronakos C. Toward further mapping
of the association between the IL2RA locus and type 1 diabetes.
Diabetes 2007 Apr;56(4):1174-6.
- Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina,
Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre
Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume
Charpentier, Thomas J. Hudson, Alexandre Montpetit, Mark Prentki,
Barry I. Posner, David J. Balding, DavidMeyre, Constantin
Polychronakos, Philippe Froguel. A genome-wide association
study identifies novel susceptibility loci for type 2 diabetes
mellitus. Nature 2007 Feb 22;445(7130):881-5. I
am the corresponding author in this paper.
- A Genome-Wide Association Study Identifies KIAA0350 as a novel
Type1 Diabetes Gene. Hakonarson H, Grant SF, Bradfield JP, Marchand
L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton
EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley
CA, Kirsch SE, Rappoport EF, Orange JS, Monos DS, Devoto M, Qu
HQ, Polychronakos C. Nature 2007 Aug
2; 448(7153):591-4. (Co-corresponding author with
H.H.).
- Qu, H. Polychronakos, C. The TCF7L2 locus and
type 1 diabetes. BMC Med Genet 2007 Aug 3;8(1):51.
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