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 Home / About Us > Dr Constantin Polychronakos > Reviews
Original articles
* Asterisk indicates trainee/employee under my supervision. Seminal papers highlighted
  • Marquette CA, Lawrence I, Polychronakos C and MF Lawrence. Impedance based DNA chip for direct Tm measurement. Talanta 2002, 56(4):763-768.
  • *Alami Chentoufi A and C Polychronakos. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 2002, 51:1383-1390.
  • *Zavalkoff SR and C Polychronakos. Evaluation of conventional blood glucose monitoring as an indicator of integrated glucose values using a continuous subcutaneous sensor. Diabetes Care, 2002, 25:1603-1606.
  • *Anjos S, Nguyen A, *Ounissi-Benkhala H, *Tessier MC and C Polychronakos. A common autoimmunity predisposing a signal peptide variant of the cytotoxic T-lymphocyte antigen-4 results in inefficient glycosylation of the susceptibility allele. Journal of Biological Chemistry, 2002, 277(48):46478-46486.
  • Polychronakos C and A *Kukuvitis. Parental genomic imprinting in endocrinopathies. European Journal of Endocrinology 2002, 147(5):561-569.
  • Ducharme FM, Chabot G, Polychronakos C, Glorieux F and B Mazer. Safety profile of frequent short courses of oral glucocorticoids in acute pediatric asthma: impact on bone metabolism, bone density, and adrenal function. Pediatrics 2003, Feb;11(2):376-83.
  • *Punthakee Z, Legault L and C Polychronakos. Prednisolone in the treatment of adrenal insufficiency: A reevaluation of relative potency. J Pediatr. 2003, Sep;143(3):402-5.
  • Macanovic A, Marquette C, Polychronakos C and MF Lawrence. Impedance-based detection of DNA sequences using a silicon transducer with PNA as the probe layer. Nucleic Acids Research 2004, Jan 22;32(2):E20.
  • *Chentoufi A, *Palumbo M and C Polychronakos. Proinsulin expression by Hassall's corpuscles in the mouse thymus. Diabetes 2004, 53(2):354-9.
  • *Kukuvitis A, Georgiou I, Syrrou M, Andronikou S, Dickerman A, *Islam A, *McCann J and C Polychronakos. Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10. J Ped Endocrinol Metab 2004, 17:1215-1220.
  • *McCann JA, *Xu YQ, *Frechette R, Guazzarotti R and Polychronakos C. The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect. J Clin Endocrinol Metab. 2004, 89(11):5700-6.
  • *Anjos S, *Tessier MC and C Polychronakos. Association of the CTLA4 gene with type 1 diabetes: independent effects of two SNPs on the same haplotype block. J Clin Endocrinol Metab 2004, 89:5700-6.
  • *Mitchell J, *Punthakee Z, Lo B, Bernard B, Chong K, Newman C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P and C Polychronakos. Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gallbladder hypoplasia: A search for the etiology of a new autosomal recessive syndrome. Diabetologia 2004, Dec;47(12):2160-7
  • *Qu H, *Tessier M-C, Hudson TJ and Polychronakos C. Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 Diabetes in a family-based study. Journal of Medical Genetics. 2005, 42(3) 266-270.
  • *Qu H, Bharaj B, Liu XQ, Curtis JA, Newhook LA, Paterson AD, Hudson TJ and C Polychronakos. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nature Genetics. 2005, 37:111-112.
  • *Anjos S, *Shao W, *Marchand L and C Polychronakos. Allelic effects on gene regulation at the autoimmunity-predisposing CTLA4 locus: a re-evaluation of the 3' +6230G>A polymorphism. Genes and Immunity 2005, 6(4):305-11.
  • Tessier MC, Qu HQ, Frechette R, Bacot F, Grabs R, Taback SP, Lawson ML, Kirsch SE, Hudson TJ and Polychronakos C. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? J Med Genet. 43:129-32 2006
  • Durinovic-Belló I, *Jelinek E, Schlosser M, Eiermann T, Boehm BO, Karges W, *Marchand L and Polychronakos C. Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-lymphocyte responses to proinsulin epitopes in HLA-DR4, DQ8 individuals. Diabetes 2005 54:S18-S24.
  • Qu H, Tessier M C Tessier, Frechette R, Bacot F, Polychronakos C. Lack of association of type 1 diabetes with the IL4R gene. Diabetologia 49:958-961, 2006.
  • Legault L, Polychronakos C. Annual incidence of type 1 diabetes in Quebec between 1989-2000 in children. Clin Invest Med. 29:10-3, 2006
  • *Qu H, *Guo F, Majewski J and Polychronakos C. Strand bias of complementary single-nucleotide polymorphisms in transcribed human sequences: evidence for functional effects of synonymous substitutions. BMC Genomics. 2006 Aug 17;7:213.
  • Durinovic-Belló, Rosinger S, Olson JA, Congia M, Ahmad RC, Rickert M, Hamp J, Kalbacher H, Drijfhout JW, Mellins ED, Al Dahouk S, Roep BO, Nepom GT, Kamradt T, Maeurer MJ, KargesW, Boehm BO, Nhan C*, Polychronakos C, McDevitt HO and Sønderstrup G. DRB1*0401-restricted human T-cell clone, specific for the major proinsulin 73-90 epitope expresses a regulatory T helper 2 phenotype. Proc Natl Acad Sci USA. 2006 103(31):11683-8,.
  • *Palumbo M, *Levi D, *Chentoufi AA and C Polychronakos. Insulin-producing thymus epithelial cell lines: generation, characterization, and evaluation of expression of beta-cell antigens and transcription factors. Diabetes 2006, 55(9):2595-601
  • Marchand L, Polychronakos C. Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Type 1 Diabetes. Diabetes 2007 Mar;56(3):709-13.
  • Qu H., Yang L., Montpetit A., Polychronakos C. Genetic control of alternative splicing in the TAP2 gene: Possible implication in the genetics of type 1 diabetes. Diabetes 2007 56:270-275,2007.
  • Qu HQ, Marchand L, Frechette R, Bacot F, Lu Y, Polychronakos C. No association of type 1 diabetes with a functional polymorphism of the LRAP gene. Molecular Immunology. 44:2145-8, 2007.
  • Qu HQ and Polychronakos C. Toward further mapping of the association between the IL2RA locus and type 1 diabetes. Diabetes 2007 Apr;56(4):1174-6.
  • Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume Charpentier, Thomas J. Hudson, Alexandre Montpetit, Mark Prentki, Barry I. Posner, David J. Balding, DavidMeyre, Constantin Polychronakos, Philippe Froguel. A genome-wide association study identifies novel susceptibility loci for type 2 diabetes mellitus. Nature 2007 Feb 22;445(7130):881-5. I am the corresponding author in this paper.
  • A Genome-Wide Association Study Identifies KIAA0350 as a novel Type1 Diabetes Gene. Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappoport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C. Nature 2007 Aug 2; 448(7153):591-4. (Co-corresponding author with H.H.).
  • Qu, H. Polychronakos, C. The TCF7L2 locus and type 1 diabetes. BMC Med Genet 2007 Aug 3;8(1):51.



Montreal Diabetes Research Center 2008
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