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 Home / About Us > Dr. Marko Horb

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Postdoc. M.Sc. Ph.D. Tech Other
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Dr. Marko Horb

Dr. Marko Horb completed his undergraduate studies in Cellular and Structural Biology with distinction at the University of Illinois at Urbana-Champaign. In 1998 he obtained his Ph.D. in Cellular and Developmental Biology from the State University of New York at Stony Brook, where he worked under the supervision of Dr. Gerald Thomsen. His thesis dealt with the role of the T-box gene in Xenopus embryogenesis. He then moved to England to pursue his postdoctoral research in the laboratory of Prof. Jonathan M.W. Slack at the University of Bath. His postdoctoral studies focused on early endoderm patterning and pancreas development in Xenopus. In 2003 he took up a position in Montreal at the Institut de Recherches cliniques de Montreal, where his lab is focused on elucidating the molecular signals responsible for specifying the various pancreatic lineages.

Research in the Horb lab is focused on elucidating the molecular signals responsible for cell fate specification in the developing pancreas, with an aim towards reprogramming other cell types into endocrine beta cells. The lab uses the amphibian, Xenopus laevis, as its model organism to identify new genes involved in pancreas development. In particular the lab has shown that pancreatic transcription factors can be used to convert liver cells into functional pancreatic beta cells. Using a transgenic transdifferentiation assay in amphibian embryos he showed that Pdx1-VP16 is sufficient to convert liver to pancreas.



� Montreal Diabetes Research Center 2008
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