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 Home / About Us > Dr. Jun-Li Liu > Bibliography
Dr. Jun-Li Liu - Bibliography (Last Five Years)

Published from McGill University
  • Y Lu, A Ponton, H Okamoto, S Takasawa, PL Herrera, and JL Liu. Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas. Amer J Physiol 2005 (in press: DOI 10.1152/ajpendo.00596.2005)
  • K Roberston, JJ Kopchick and JL Liu. Growth hormone receptor deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice. Amer J Physiol 2005 (in press: DOI 10.1152/ajpendo.00600.2005)
  • Z Tang, R Yu, Y Lu, AF Parlow and JL Liu. Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice. Amer J Physiol 2005; 289: E288-295
  • Y Guo, Y Lu, D Houle, K Robertson, Z Tang, JJ Kopchick, YL Liu and JL Liu. Pancreatic islet-specific expression of an IGF-I transgene compensates islet cell growth in growth hormone receptor gene deficient mice. Endocrinology 2005; 146: 2602-2609
  • Lu Y, Herrera PL, Guo Y, Sun D, Tang Z, LeRoith D, Liu JL. Pancreatic specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes. Diabetes 53:3131-3141 (2004).
  • Liu JL, Coschigano KT, Robertson K, Lipsett M, Guo Y, Kopchick JJ, Kumar U, Liu YL. Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol 287:E405-413 (2004).
  • Yu R, Yakar S, Liu JL, Lu Y, LeRoith D, Miao D, Liu JL. Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance. Mol Cell Endocrinol 204:31-42 (2003).(Download Article)
  • Tivesten Å, Bollano E, Andersson I, Fitzgerald S, Caidahl K, Sjögren K, Skott O, Liu JL, LeRoith D, Mobini R, Isaksson OGP, Jansson JO, Ohlsson C, Bergström G, Isgaard J. Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in mice. Endocrinology 143:4235-42 (2002).
  • Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110:771-81 (2002).
  • Sjögren K, Sheng M, Moverare S, Liu JL, Wallenius K, Törnell J, Isaksson O, Jansson J-O, Mohan S, Ohlsson C. Effects of liver-derived insulin-like growth factor I on bone metabolism in mice. J Bone Mineral Res 17:1977-87 (2002).
  • Liu YL, Yakar S, Otero-Corchon V, Low MJ, Liu JL. Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-I. Mol Cell Endocrinol 189:97-103 (2002).(Download Article)
  • Wallenius K, Sjogren K, Peng XD, Park S, Wallenius V, Liu JL, Umaerus M, Wennbo H, Isaksson O, Frohman L, Kineman R, Ohlsson C, Jansson JO. Liver-derived IGF-I regulates growth hormone secretion at the pituitary level in mice. Endocrinology 142:4762-70 (2001).
  • Sjögren K, Wallenius K, Liu JL, Bohlooly-Y M, Pacini G, Svensson L, Törnell J, Isaksson OGP, Ahrén B, Jansson JO, Ohlsson C. Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism. Diabetes 50:1539-45 (2001).
  • Lu C, Schwartzbauer G, Sperling MA, Devaskar SU, Thamotharan S, Robbins PD, McTiernan CF, Liu JL, Jiang J, Frank SJ, Menon RK. Demonstration of direct effects of growth hormone on neonatal cardiomyocytes. J Biol Chem 276:22892-900 (2001).
  • Hellstrom A, Perruzzi C, Ju M, Engstrom E, Hard AL, Liu JL, Albertsson-Wikland K, Carlsson B, Niklasson A, Sjodell L, LeRoith D, Senger DR, Smith LE. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci USA 98: 5804-8 (2001).
  • Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia WM, LeRoith D. Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity. Diabetes 50:1110-18 (2001).
  • Liu JL, Yakar S, LeRoith D. Mice deficient in liver production of insulin-like growth factor I display sexual dimorphism in growth hormone-stimulated postnatal growth. Endocrinology 141:4436-41 (2000).


Reviews, Editorials, Book Chapters


  • JL Liu. Dose IGF-I stimulate pancreatic islet cell growth? Cell Biochem Biophy 2005; (submitted)
  • JL Liu (guest editor). Conditional gene targeting in mice. (A special issue of the journal) Endocrine 2002; 19: 219-278. Humana Press. Introduction on page 219-220
  • Patel YC, Liu JL, Galanopoulou A, Papachristou DN. Production, action and degradation of somatostatin. In: LS Jefferson & AD Cherrington (Ed) Handbook of Physiology: Section 7, Volume II: The Endocrine Pancreas and Regulation of Metabolism. American Physiological Society. 267-302 (2001).
  • LeRoith D, Bondy C, Yakar S, Liu JL, Butler A. The Somatomedin hypothesis: 2001. Endocrine Rev 22:53-74 (2001).
  • Liu JL, Yakar S, LeRoith D. Conditional knockout of mouse insulin-like growth factor-I gene using the Cre/loxP system. Proc. Soc. Exp. Biol. Med. 223:344-51 (2000).
  • Yakar S, Liu JL, LeRoith D. The growth hormone-insulin-like growth factor-I system: Implications for organ growth and development. Pediatric Nephrology 14:544-9 (2000).

� Montreal Diabetes Research Center 2008
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