News

    
Directory / Bottin
Contact Us
Directions / Maps
Steering Commitee
Events & Seminars
MDRC Core Facilities
Scientific Links
Education & Employment

    
Grants
Donations
Industrial Partners
    
JDRF
CDA
QDA
ADA
IDF
NIH / NIDDK
Alfediam
EASD


 Home / About Us > Dr. Vincent Poitout > Bibliography
Dr. Vincent Poitout - Bibliography (Last Five Years)

Original, Peer-Reviewed Publications
  • S. Jacqueminet, I. Briaud, C. Rouault, G. Reach, V. Poitout. Inhibition of insulin gene expression by long-term exposure of pancreatic beta-cells to palmitate is dependent upon the presence of a stimulatory glucose concentration. Metabolism 2000, 49: 532-536.
  • I. Briaud, C. Rouault, D. Bailbé, B. Portha, G. Reach, V. Poitout. Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats. Horm Metab Res 2000, 32: 53-56.
  • I. Briaud, J.S. Harmon, C.L. Kelpe, V.B. Segu, V. Poitout. Lipotoxicity of the pancreatic ß-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 2001, 50: 315-321.
  • J.S. Harmon, C.E. Gleason, Y. Tanaka, V. Poitout, R.P. Robertson. Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene expression in Zucker Diabetic Fatty rats. Diabetes 2001, 50: 2481-2486.
  • M. Guerre-Millo, C. Rouault, P. Poulain, J. André, V. Poitout, J.M. Peters, F.J. Gonzales, J.C. Fruchart, G. Reach, B. Staels. PPARa null mice are protected from high-fat diet-induced insulin resistance. Diabetes 2001, 50: 2809-2814.
  • I. Briaud, C.L. Kelpe, L.M. Johnson, P.O.T. Tran, V. Poitout. Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic vs. normoglycemic rats. Diabetes 2002, 51: 662-668.
  • C.L. Kelpe, L.M. Johnson, V. Poitout. Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of Langerhans. A Study Using Adenoviral Expression of Diacylglycerol Acyltransferase. Endocrinology 2002, 143: 3326-3332.
  • S. Matsumoto, S. Qualley , S. Goel , D. Hagman, Ian R. Sweet, V. Poitout, D. M. Strong , R. P. Robertson, J. Reems. Effect of the two-layer [University of Wisconsin solution-Perfluorochemical + O2] method of pancreas preservation on human islet isolation, as assessed by the Edmonton isolation protocol. Transplantation 2002, 74: 1414-1419.
  • P.C. Guest, S.M. Abdel-Halim, D.J. Gross, A. Clark, V. Poitout, R. Amaria, C.G. Ostenson, J.C. Hutton. Proinsulin processing in the Goto-Kakizaki (GK) rat. J Endocrinol 2002, 175: 637-647.
  • K. Yaekura, R. Julyan, L. Hays, M. Donelan, D. Baskin, V. Poitout, C.J. Rhodes. Insulin secretory deficiency and glucose intolerance in Rab3A null mice. J Biol Chem 2003, 278: 9715-9721.
  • C.L. Kelpe, P.C. Moore, S.D. Parazzoli, B. Wicksteed, C.J. Rhodes, V. Poitout. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem 2003, 278: 30015-30021.
  • S. Parker, P.C. Moore, L.M. Johnson, V. Poitout. Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate. Metabolism 2003, 52:1367-1371.
  • R. Roduit, C. Nolan, C. Alarcon, P. Moore, A. Barbeau, V. Delghingaro-Augusto, E. Przybykowski, J. Morin, F. Massé, B. Massie, N. Ruderman, C. Rhodes, V. Poitout, M. Prentki. A Role for the malonyl-CoA / long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and non-fuel stimuli. Diabetes 2004, 53: 1007-1019.
  • P.C. Moore, M.A. Ugas, D.K. Hagman, S.D. Parazzoli, V. Poitout. Evidence against the involvement of oxidative stress in fatty-acid inhibition of insulin secretion. Diabetes 2004, 53: 2610-2616.
  • M. F. Pino, D. Z. Ye, K. D. Linning, C.D. Green, B. Wicksteed, V. Poitout, L. K. Olson. Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic ß cells via reduced nuclear factor binding to the A5/core and Z element. Mol Endocrinol 2005, 19: 1343-1360.
  • L. Zhao, M. Guo, T. Matsuoka, D.K. Hagman, S.D. Parazzoli, V. Poitout, R. Stein. The islet beta-cell-enriched MafA activator is a central regulator of insulin gene transcription. J Biol Chem 2005, 280: 11887-11894.
  • H. Bihan, C. Rouault, V. Poitout, G. Reach, B. Staels, M. Guerre-Millo. PPARa contributes to the adaptive response of pancreatic islets to hyperglycemia. FEBS Letters 2005, 579: 2284-2288.
  • D.K. Hagman, S.D. Parazzoli, V. Poitout. Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. J Biol Chem 2005, 280: 32413-32418.
  • E. Oseid, P.C. Moore, J. Luo, D.C. Lin, V. Poitout. Essential role for GPR40 in glucose homeostasis and fatty-acid potentiation of insulin secretion. Submitted for publication.
Communications
  • I. Briaud, C.L. Kelpe, J.S. Harmon, S.A. Metz, V. Poitout. Palmitate-induced impairment of insulin gene expression in pancreatic beta-cells is associated with intracellular accumulation of triacylglycerols. J Investig Med 2000, 48: A113.
  • P.O.T. Tran, C.E. Gleason, V. Poitout, R.P. Robertson. Sodium salicylate blocks interleukin-1ß-induced cyclooxygenase gene expression and inhibition of insulin secretion. J Investig Med 2000, 48: A113.
  • P.O.T. Tran, C. E. Gleason, V. Poitout, R. P. Robertson. Inhibition of cyclooxygenase 2 (COX 2) and type 3 prostaglandin E receptor (EP3) gene expression are mechanisms whereby sodium salicylate (SS) interferes with IL 1 ? inhibition of insulin secretion. Diabetes 2000, 49/Suppl 1: A261.
  • I. Briaud, C. L. Kelpe, P.O.T. Tran, V. Poitout. High-fat diet impairs beta-cell function in Goto-Kakizaki rats independently of lipotoxicity. Diabetes 2000, 49/Suppl 1: A262.
  • J. S. Harmon, I. Briaud, R. P. Robertson, V. Poitout. An improved method for measurement of triacylglycerol content in pancreatic islets. Diabetes 2000, 49/Suppl 1: A263
  • I. Briaud, C. L. Kelpe, J. S. Harmon, S. A. Metz, V. Poitout. Palmitate inhibition of glucose-induced insulin gene expression is associated with increased intracellular accumulation of neutral lipids in pancreatic beta-cells. Diabetes 2000, 49/Suppl 1: A415.
  • J.S. Harmon, C.E. Gleason, Y. Tanaka, V. Poitout, R.P. Robertson. Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene expression in Zucker Diabetic Fatty rats. Diabetes 2001, 50/Suppl 2: A319.
  • I. Briaud, C.L. Kelpe, L.M. Johnson, P.O.T. Tran, V. Poitout. Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic vs. normoglycemic rats. Western Islet Club, San Francisco, CA, September 2001.
  • I. Briaud, C.L. Kelpe, L.M. Johnson, P.O.T. Tran, V. Poitout. Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic vs. normoglycemic rats. Beta-cell biology for the 21st century. National Institutes of Health, Bethesda, MD, November 2001.
  • R. Roduit, C. Alarcon, F. Massé, C.L. Kelpe, V. Poitout, C.J. Rhodes, M. Prentki,. Overexpressing malonyl-CoA decarboxylase in the cytosol alters lipid partitioning and glucose-induced insulin secretion in pancreatic beta-cells. Beta-cell biology for the 21st century. National Institutes of Health, Bethesda, MD, November 2001.
  • V. Poitout, C.L. Kelpe, L. Johnson. Overexpression of Diacylglycerol-Acyltransferase inhibits glucose-induced insulin secretion in isolated rat islets of Langerhans. Diabetes 2002, 51/Suppl 2: A1.
  • K. Yaekura, R. Julyan, B.L. Wicksteed, L.B. Hays, C. Alarcon, D. Baskin, V. Poitout, L.H. Philipson, C.J. Rhodes. Rab3A Null Mice Develop a Pancreatic ?-cell Defect Glucose Intolerance due to an Insulin Exocytotic Defect. Diabetes 2002, 51/Suppl 2: A72.
  • S. Matsumoto, S. Qualley , S. Goel , D. Hagman, Ian R. Sweet, V. Poitout, D. M. Strong, R. P. Robertson, J. Reems. The effect of the two-layer [University of Wisconsin solution (UW) / Perfluorochemical+ O2] method on human islet isolation as assessed by the Edmonton isolation protocol. American Transplant Meeting 2002.
  • H. Bihan, C. Rouault, M. Guerre-Millo, V. Poitout, B. Staels, G. Reach. Rôle de PPAR? dans l’insulino-sécrétion: Etude fonctionnelle des îlots de Langerhans de souris invalidées pour PPAR?. ALFEDIAM 2003.
  • C.L. Kelpe, C.S. Sutton, P.C. Moore, B. Wicksteed, C.J. Rhodes, V. Poitout. Fatty acids inhibit insulin gene transcription in isolated rat islets of Langerhans. Keystone symposium “Towards understanding islet biology” 2003.
  • C.L. Kelpe, P.C. Moore, C.S. Sutton, Susan D. Parazzoli, B. Wicksteed, C.J. Rhodes, V. Poitout. Palmitate inhibition of insulin gene expression in isolated rat islets is transcriptional and mediated by de novo ceramide synthesis. Diabetes 2003, 52/Suppl 1: A377.
  • M. Prentki, C. Nolan, C. Alarcon, C. Kelpe, E. Przybykowski, J. Morin, F. Masse, N. Ruderman, C. Rhodes, V. Poitout, R. Roduit. A role for malonyl-CoA and lipid signaling in the regulation of insulin secretion in response to both fuel and non-fuel stimuli. Diabetes 2003, 52/Suppl 1: A383.
  • V. Poitout, P.C. Moore, C.S. Sutton, S.D. Parazzoli, B. Wicksteed, C.J. Rhodes, C.L. Kelpe. Mechanisms of fatty acid inhibition of insulin gene expression in isolated rat islets. Diabetologia 2003, 46/Suppl 2: A 177.
  • D.K. Hagman, M.A. Ugas, P.C. Moore, S.D. Parazzoli, V. Poitout. Fatty-acid inhibition of insulin secretion: In search of a mechanism. Western Region Islet Study Group Meeting, Seattle, WA, September 2003.
  • M.A. Ugas, P.C. Moore, V. Poitout. Fatty-acid inhibition of insulin secretion: In search of a mechanism. National Conferences on Undegraduate Research, Indianapolis, IN, April 2004.
  • D.K. Hagman, S.D. Parazzoli, V. Poitout. Prolonged exposure to palmitate reduces PDX-1 and MafA binding to the insulin gene promoter. Western Region Islet Study Group Meeting, Catalina Island, CA, October 2004.
  • D.K.Hagman, S.D. Parazzoli, V. Poitout. Prolonged exposure of isolated rat islets to palmitate reduces PDX-1 and MafA binding to the insulin gene promoter. Keystone Symposium: Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies, Keystone, CO, January 2005.
  • D.K. Hagman, S.D. Parazzoli, V. Poitout. Prolonged Exposure of Isolated Rat Islets to Palmitate Reduces PDX-1 and MafA Binding to the Insulin Gene Promoter. Diabetes 2005, 54/Suppl 1: A399.
  • P.C. Moore, D.C. Lin, J. Luo, V. Poitout. Deletion of the GPR40 gene impairs fatty-acid potentiation of insulin secretion in isolated mouse islets. Diabetes 2005, 54/Suppl 1: A83.

 

 

© Montreal Diabetes Research Center 2008
Home / About Us   News   Directory / Bottin   Contact Us