Contact info

Dr Jacques Turgeon
CRCHUM � Pavillon S
850, Saint-Denis � Room S06.250
Montreal, QC H2X 0A9

Tel: 1-514-890-8045
Fax: 1-514-412-7978
E-mail: [email protected]

Research keywords

Since spring 2007, Dr Jacques Turgeon has been appointed Director of Research at the Centre hospitalier de l'Universit� de Montr�al. From 2005-2007 he was Vice-Rector � Research, Universit� de Montr�al and from 2000-2005, he has served as Dean of the Facult� de pharmacie, Universit� de Montr�al. He received his Bachelor degree in Pharmacy in 1983 from Laval University in Quebec city followed by an MSc degree in pharmacokinetics and a PhD degree in drug metabolism from the same institution in 1985 and 1988, respectively. He completed post-doctoral studies from 1988 to 1990 in the department of Clinical Pharmacology, Vanderbilt University in Nashville, U.S.A.

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1- Turgeon J, Daleau P, Bennett PB, Wiggins SS, Selby L and Roden DM. Block of IKs, the slow component of the delayed rectifier K⁺ current, by the diuretic agent indapamide in guinea pig ventricular myocytes. Circ Res 75:879-886, 1994.

2- Morissette P, Hreiche R and Turgeon J. Modulatory role of verapamil treatment on the cardiac electrophysiological effects of cisapride. Can J Physiol Pharmacol 84:1285-1290, 2006.

3- Michaud V, Vanier MC, Brouillette D, Roy D, Verret L, Noel N, Taillon I, O'Hara G, Gossard D, Champagne M, Goodman K, Renaud Y, Brown A, Phillips M, Ajami AM and Turgeon J. Combinaison of phenotype assessments and CYP2C9-VKORC1 polymorphisms in the determination of warfarin dose requirements in heavily medicated patients. Clin Pharmacol Ther 83(5):740-748, 2008.

4- Couture L, Nash J and Turgeon J. The ATP-Binding Cassette (ABC) transporters and their implication in drug disposition: a special look at the heart. Pharmacol Rev 58:244-258, 2006.

5- Michaud V, Frappier M, Dumas MC and Turgeon J. Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism. PLoS ONE 5(12):e15666, December 2010.

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Research interests of Dr Turgeon have always been directed towards the study of factors responsible for intersubject variability in drug response. More specifically, he has developed expertise in the role of pharmacogenetics in cardiovascular drug actions. Among his favourite topics were the study of drug-drug interactions leading to pharmacodynamics modulation of antiarrhythmic drug action. Dr Turgeon has integrated in his research approaches in vitro (patch-clamp technique, in vitro metabolism and molecular biology) models as well as designed and performed studies in healthy volunteers and patients. Dr Turgeon is recognized internationally for his work on CYP450s and mechanisms of drug-drug interactions. He has published more than 100 referred articles and more than 300 abstracts. Dr Turgeon has received numerous prizes for his research activities as well as recognition by the students for his teaching skills. He is a member of numerous societies and has been acting on the committees of several granting agencies for several years. He has been the Director of the Quebec Cardiovascular Network of the FRQS and the Research Director of the Quebec Heart Institute, Laval Hospital.